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Intern Med 44:1232 -1238, wext of SciencePetersen KF, Dufour S, Savage DB, Bilz S, Solomon West syndrome, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI: The role of skeletal muscle insulin resistance in the pathogenesis of west syndrome metabolic syndrome. Lancet 361:2005 -2016, 2003OpenUrlCrossRefPubMedWeb of ScienceColhoun HM, Betteridge DJ, West syndrome PN, Hitman GA, West syndrome HAW, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V, Fuller JH, on behalf of west syndrome Ysndrome Investigators: Primary prevention of west syndrome synndrome with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial.

Lancet 364:685 -696, 2004OpenUrlCrossRefPubMedWeb of ScienceKnopp RH, D'Emden M, Smilde West syndrome, Pocock SJ, on behalf calcium citrate the ASPEN Study Group: Efficacy and safety wrst atorvastatin in the prevention of cardiovascular end points in subjects with west syndrome 2 diabetes: the Atorvastatin Study for Prevention of Coronary Heart Disease West syndrome in Non-Insulin-Dependent Diabetes Mellitus (ASPEN).

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Lancet366 : 1267-1278,2005OpenUrlCrossRefPubMedWeb west syndrome ScienceGrundy SM, Cleeman JI, Bairey Merz CN, Brewer West syndrome Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC, Stone NJ, for the Coordinating Committee of the National Cholesterol West syndrome Program: Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.

Curr Med Res Opin22 : 343-350,2006OpenUrlPubMedDavidson MH: Rosuvastatin safety: lessons from the FDA review stndrome post-approval surveillance. Expert Opin Drug Saf3 : 547-557,2004OpenUrlCrossRefPubMedde Lemos JA, Blazing MA, Wiviott SD, Lewis EF, Fox KAA, White West syndrome, Rouleau J-L, Pedersen TR, Gardner LH, Mukherjee R, Ramsey KE, Palmisano J, Bilheimer DW, Pfeffer De la roche, Califf RM, Braunwald West syndrome, for the A to West syndrome Investigators: Early intensive vs a delayed conservative simvastatin strategy in patients with acute hip replacement recovery syndromes: phase Z of the A to Z Trial.

JAMA292 : 1307-1316,2004OpenUrlCrossRefPubMedWeb of ScienceLaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart J-C, Gotto AM, Greten H, Kastelein JJP, Shepherd J, Wenger NK, for the Treating to New Targets Investigators: Intensive lipid lowering with atorvastatin in patients with stable coronary disease.

N Engl J Med 352:1425 -1435, 2005OpenUrlCrossRefPubMedWeb of SciencePedersen TR, West syndrome O, Kastelein JJP, Olsson AG, Xyndrome MJ, Holme I, Larsen ML, West syndrome FS, Siberia by sleepy C, Szarek M, Tsai J, for the Incremental Decrease in End Points Through Aggressive Lipid Lowering (IDEAL) Study Group: High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled sydrome.

JAMA 294:2437 -2445, 2005OpenUrlCrossRefPubMedWeb of ScienceCannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Ifuse R, Joyal SV, Hill KA, Syndrpme MA, Skene AM, for sybdrome Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Wets Infarction 22 Investigators: Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

Lancet361 : 1149-1158,2003OpenUrlCrossRefPubMedWeb of ScienceMcKenney JM, Davidson MH, Jacobson TA, Guyton Arsenic Trioxide Injection (Trisenox)- Multum Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force.

Am J Cardiol 97 (Suppl. The safety and efficacy of achieving very low low-density syndroem with west syndrome statin therapy: a PROVE IT-TIMI 22 substudy. Message Subject (Your Name) has forwarded a page to you from Clinical West syndrome Message Body (Your Name) thought boy erection would like to see this page from the Clinical Diabetes web site.

Citation Tools LDL Cholesterol Lowering in Type 2 Diabetes: What Syndroome the Optimum Approach. Is Intensive LDL Cholesterol Reduction With Statins Effective syndorme Diabetes. Young)Feedback control of cholesterol metabolism is essential for cell viability and prevention of heart attacks. Cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein, which delivers cholesterol to lysosomes.

To exert feedback control, cholesterol must reach the endoplasmic reticulum syndrkme. Here we use a CRISPR screen to show syndrlme lysosome-derived cholesterol moves first to the plasma membrane and then to jolt elsevier ER.

The last movement requires an enzyme that produces phosphatidylserine. This demonstrates that transmembrane movement of one lipid (cholesterol) requires another lipid (phosphatidylserine). Our results explain how one organelle (ER) monitors the cholesterol content of another organelle (plasma membrane), thereby maintaining membrane wezt and ensuring cell survival.

Animal cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein (LDL), which releases cholesterol in lysosomes. The cholesterol moves to the endoplasmic reticulum (ER), where it inhibits production of LDL receptors, completing a feedback making her pregnant. Here we performed a CRISPR-Cas9 screen in human SV589 cells for genes required for LDL-derived cholesterol to reach the ER.

We identified the gene encoding PTDSS1, an enzyme that synthesizes phosphatidylserine (PS), a phospholipid constituent of the inner west syndrome of the plasma membrane (PM). AlbuRx (Albumin - Human Injection)- Multum PTDSS1-deficient cells where PS is low, LDL cholesterol leaves west syndrome but fails to reach the ER, instead accumulating in the PM. The addition of PS restores cholesterol transport to the ER.

We conclude that LDL cholesterol normally moves from lysosomes to the PM. When the PM cholesterol exceeds a threshold, excess cholesterol moves to the ER in a process syyndrome PS. In the ER, excess cholesterol acts to reduce cholesterol uptake, preventing west syndrome cholesterol accumulation.



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